Manufacturing excellence in tablet production

Product Overview

Tinidazole 250mg tablets are a reliable antiprotozoal medication manufactured by Taj Pharma under strict WHO-GMP standards. Each tablet contains 250mg of active pharmaceutical ingredient, making it suitable for various parasitic infections.

Key Specifications

  • Strength: 250mg per tablet
  • Form: Film-coated tablet
  • Manufacturer: Taj Pharma
  • Certification: WHO-GMP Certified
  • Packaging: Blister packs (10 tablets per strip)
  • Storage: Room temperature (15-30°C)

Approved Indications

Tinidazole 250mg is indicated for treatment of the following infections

Trichomoniasis

Effective treatment for Trichomonas vaginalis infections with high cure rates and excellent tolerability.

Giardiasis

Proven efficacy against Giardia lamblia with rapid symptom relief and complete parasitic clearance.

Amebiasis

Effective for both intestinal and extraintestinal amebiasis caused by Entamoeba histolytica.

Dosage & Administration

Standard dosing recommendations for Tinidazole 250mg

Trichomoniasis

  • Adults: 8 tablets (2g) as single dose
  • Alternative: 4 tablets (1g) twice daily for 2 days
  • Children: 50 mg/kg single dose
  • Timing: Take with food to minimize GI upset

Giardiasis

  • Adults: 8 tablets (2g) daily for 5-7 days
  • Alternative: 4 tablets (1g) daily for 3 days
  • Children: 50 mg/kg/day for 5-7 days
  • Timing: Take with meals

Amebiasis (Intestinal)

  • Adults: 8 tablets (2g) daily for 3 days
  • Children: 50 mg/kg/day for 3 days
  • Follow-up: Use luminal agent for cyst elimination
  • Timing: Take with food

Amebiasis (Extraintestinal)

  • Adults: 8 tablets (2g) daily for 5-10 days
  • Children: 50 mg/kg/day for 5-10 days
  • Note: May require additional therapy
  • Timing: Take with meals

Pharmacokinetics

How Tinidazole 250mg is absorbed, distributed, and eliminated

Absorption

Rapidly absorbed from the gastrointestinal tract. Peak plasma levels achieved within 1-2 hours of oral administration.

Distribution

Widely distributed throughout body tissues and fluids. Crosses blood-brain barrier and placental barrier. Protein binding: 12%.

Metabolism

Hepatic metabolism produces active metabolites. Half-life of 12-14 hours allows for convenient dosing schedules.

Elimination

Primarily renal elimination (60-80%). Metabolites and unchanged drug excreted in urine. Biliary excretion also occurs.

Clinical Efficacy

Evidence-based efficacy data from clinical trials

Trichomoniasis

  • Cure Rate: 90-95%
  • Single Dose Efficacy: 90-95%
  • Symptom Relief: 2-3 days
  • Recurrence Rate: <5%
  • Partner Treatment: Essential

Giardiasis

  • Cure Rate: 90-100%
  • Symptom Relief: 3-5 days
  • Cyst Clearance: 95-100%
  • Recurrence Rate: <2%
  • Immunocompromised: May need longer therapy

Amebiasis (Intestinal)

  • Cure Rate: 90-95%
  • Symptom Relief: 3-7 days
  • Cyst Clearance: 95%+
  • Luminal Agent: Recommended

Amebiasis (Extraintestinal)

  • Cure Rate: 85-95%
  • Abscess Resolution: 7-14 days
  • Combination Therapy: Often needed
  • Drainage: May be required

Safety Profile

Side effects and safety information

Common Side Effects (>1%)

  • Metallic taste (10-15%)
  • Nausea (5-10%)
  • Headache (3-5%)
  • Anorexia (2-3%)
  • Diarrhea (2-3%)
  • Dizziness (1-2%)

Serious Adverse Reactions (<1%)

  • Seizures
  • Peripheral neuropathy
  • Severe hypersensitivity
  • Hepatotoxicity
  • Hematologic abnormalities
  • Pancreatitis

Drug Interactions

Important interactions and contraindications

Major Interactions

  • Alcohol: Disulfiram-like reaction - AVOID
  • Warfarin: Increased anticoagulant effect
  • Lithium: Increased lithium levels
  • Phenobarbital: Decreased tinidazole levels

Contraindications

  • Hypersensitivity to nitroimidazoles
  • First trimester pregnancy (relative)
  • Concurrent disulfiram use
  • Blood dyscrasias

Packaging & Storage

Product packaging and storage information

Packaging Details

  • Blister packs: 10 tablets per strip
  • Carton: 10 strips (100 tablets)
  • Film-coated tablets for easy swallowing
  • Child-resistant packaging available
  • Tamper-evident sealing

Storage Instructions

  • Store at room temperature (15-30°C)
  • Protect from light and moisture
  • Keep in original blister pack
  • Keep away from children
  • Shelf life: 3 years from manufacturing date

Quality Assurance

Manufacturing standards and quality control

WHO-GMP Certified

Manufactured under strict WHO-GMP standards ensuring highest quality and safety.

Quality Testing

Every batch undergoes rigorous testing for purity, potency, and safety.

Regulatory Compliance

Complies with international pharmaceutical standards and regulations.

Need More Information?

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